Lithium treatment damages more than just the thyroid ( #hyperparathyroidism )

Everyday I wake up thinking I will add to this blog. Almost every day I feel too anxious, weak, confused and a lot of other unpleasant stuff such that I write nothing. Day after day disappears and… well, my life is disappearing, while more and more people are being labelled as bipolar.

I am not a great advert for what happens when in recovery, but at least I am still here, which I am sure I would not be, had I taken all the drugs prescribed.

People who are new to bipolar are still being given lithium as a treatment without the potential consequences being explained.

It is a subject I have thought about for ages. I have had lots of blood tests… I hope one day to have more energy, get to the bottom of this and explain more about how much lithium treatment has affected me. Today, I have just enough energy to post the following which is from:

Note: Dr Pomeranz is not associated with this site… we just feel strongly that what he says needs to be seen, especially by doctors who come into contact with those being treated with lithium.

Hyperparathyroidism Resulting From Lithium Treatment Remains Underrecognized

By Jay M. Pomerantz, MD | March 26, 2010

Dr Pomerantz practices psychiatry in Longmeadow, Mass, and is assistant clinical professor of psychiatry at Harvard Medical School in Boston.

Until recently, I never paid much attention to the possibility that abnormalities of the parathyroid glands could be relevant to patients in my practice. But I decided to learn more about this issue when one of my patients with bipolar disorder who had been treated with lithium(Drug information on lithium) told me that she had been given a diagnosis of a parathyroid adenoma after her primary care physician noted hypercalcemia on routine testing. Since undergoing successful surgery to remove the adenoma, she is feeling much sharper mentally and more energetic.

Lithium continues to be the gold standard for the treatment of bipolar disorder. It is also helpful for related diagnoses, such as schizoaffective disorder and cyclic major depression. In addition to watching out for the well-known complications of lithium treatment—hypothyroidism and decreased renal function—health care providers should be aware of hyperparathyroidism.

Development of Hyperparathyroidism 
The parathyroid glands are 4 small structures located on the posterior surface of the thyroid gland, which monitor calcium levels in the blood and release parathyroid hormone (PTH).

PTH is a peptide that acts to increase the concentration of calcium in the blood by enhancing the release of calcium from bones. In addition, PTH acts on the kidneys to increase active reabsorption of calcium from distal tubules as well as to increase the excretion of phosphate, also leading to more free calcium in circulation. Finally, PTH raises calcium levels by increasing the production of activated vitamin D, which enhances absorption of calcium by the intestine.

Primary hyperparathyroidism usually results from an adenoma in a single gland, although other causes may be double adenoma or hyperplasia in multiple glands. Previous exposure to radiation in the facial or neck area and certain medications, including thiazide diuretics, may cause primary hyperparathyroidism. In some families, the disease may be inherited. Parathyroid cancer is an extremely rare cause of primary hyperparathyroidism.

Secondary hyperparathyroidism results from any medical condition that causes low calcium levels. This is most often due to kidney failure and the consequent rise in phosphate levels. Vitamin D deficiency is another possible cause.

The lithium connection. It turns out that lithium, a mainstay in the treatment of bipolar disorder, is associated with an increased incidence of hyperparathyroidism. Approximately 15% to 20% of patients receiving long-term lithium treatment show elevated calcium levels, although only a few of these patients also have significant elevations of PTH levels and clinical symptoms of hyperparathyroidism. Interestingly, lithium-associated clinical hyperparathyroidism is almost always caused by a single parathyroid adenoma rather than 4-gland hyperplasia.1

The first case of lithium-associated hyperparathyroidism (LAH) was reported in 1973,2 and many additional reports followed. It appears that longer duration of treatment is associated with an increased incidence of LAH.3Curiously, about 75% of patients receiving lithium in whom LAH develops are women, which is consistent with the overall higher prevalence of hyperparathyroidism in women and unlike the gender-neutral ratio typical of bipolar disorder and lithium use.4

Rather than considering the cessation of lithium treatment when LAH is discovered, which may or may not reverse the calcium and other abnormalities, the usual procedure is to surgically intervene and remove the offending parathyroid glands.

Effects of Hyperparathyroidism
When a parathyroid gland enlarges and produces too much PTH, the blood calcium level becomes high, bones may lose calcium, and kidneys may excrete too much calcium. These changes may give rise to symptoms and signs such as polyuria, thirst, fractures, and kidney stones.

Neuropsychiatric symptoms associated with primary hyperparathyroidism include anxiety as well as cognitive and psychotic presentations. However, the most common presentation is depression with associated apathy.5 In a prospective study of 34 patients with hyperparathyroidism, Velasco and colleagues6 found that approximately one-third of participants had no psychiatric symptoms, one-third had affective symptoms (with or without paranoia), and one-third had cognitive impairment. Affective symptoms were most common in patients with modest elevations in electrolyte levels, while cognitive deficits were more often related to higher calcium concentrations.

Hypercalcemia. The severity of psychiatric symptoms in patients with hyperparathyroidism often correlates with the increase in serum calcium levels. Calcium performs a crucial role in nerve conduction. Consequently, it is no surprise to find out that some common symptoms of parathyroid hyperactivity and high calcium levels are related to the nervous system.

Other symptoms have to do with the muscular system, which uses changes in intracellular calcium concentration to initiate and transmit the command to contract muscle fibers. Improper regulation of calcium levels may result in muscle cramps and weakness. The heart is a muscle, and therefore its conduction system is also vulnerable, with possible shortening of the QT interval, rhythm disturbances, and even cardiac death.

The skeletal system not only functions as the reservoir of calcium for the body, but calcium phosphate(Drug information on calcium phosphate) is an essential ingredient of bone tissue. Consequently, a hyperactive parathyroid system contributes to osteoporosis and vulnerability to bone fractures.

When hypercalcemia is present, it is important not only to screen for hyperparathyroidism but also to rule out other possible underlying conditions, such as malignancy and drug-induced elevations in calcium levels.

Case Note
Already, early in the process of screening for elevated calcium levels in my many patients who are receivinglithium(Drug information on lithium), I have identified a patient with hypercalcemia and a markedly elevated PTH level, which may indicate hyperparathyroidism. She is a 50-year-old woman with schizoaffective disorder who has been receiving long-standing lithium therapy and is undergoing further evaluation by an endocrinologist. All of us are hopeful that her recent cognitive decline and mental apathy will prove to be reversible.

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Parathyroid, #Parathyroidism, #Hyperparathyroidism, #Lithium

Glands and Moods

I am continuing to research the links between glands and mood. We have a lot of glands in our bodies and each one has a role to play in helping us to have the right mood for each situation and life event. Any gland failing to work as it needs to may manifest as a mood disorder and these days this is likely to be labelled as bipolar disorder.

At this time I have a special interest in the parathyroid glands. We have four of these tiny glands in the back of our necks. It only needs one of the four to be producing too much parathyroid hormone to impact on our energy levels and impact on our moods. The parathyroid glands are just part of our endocrine system. It is unlikely to be the main factor in mood control for most people, but if you have one or more faulty parathyroid glands, will your doctor know about this? It is more likely at this time that you will labelled with a mood disorder, meaning that the physical causes are unknown. For most parts of the NHS this results in focus on mental health with almost no further consideration  of any diagnosis or treatment for physical health.

Some people have more than one faulty parathyroid gland. The cure is simple: remove the faulty glands which for a surgeon are easily recognized as these are the enlarged ones. Size is pretty well everything when it comes to the parathyroid glands.

At there are many photographs of faulty parathyroid glands that have been removed. In this example all four glands have been removed from one patient. The smaller/least-faulty gland was returned to allow the patient to recover from many of their physical and emotional troubles.

parathyroid glands From

55-year-old female
Parathyroid Hyperplasia
Pre-op Calcium 11.3
Pre op PTH 116

Having three out of four parathyroids affected is rare, although the chances of more than one parathyroid gland being faulty increases if you have ever taken  lithium tablets.

We need to know about the causes, else the mood disorder returns.

If you have been labelled as bipolar, please do not do what I did and spend 14 years working on understanding and eliminating triggers, while ignoring the causes.

In this article I only mention one physical health issue that can lead to mood problems. There are hundreds of other possibilities and it is important to at least rule them out. If you quickly want to find out more about parathyroidism then I can say the site I found most useful in 2011 and in 2012 has been:

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