Slow-release lithium was perhaps a myth / Priadel to be discontinued in the UK

How quickly does lithium carbonate dissolve?

I am slightly saddened that the Priadel brand of lithium carbonate is to be discontinued in the UK, as that was the only brand I took every evening from 1998 to 2011 (other than a year taking 200mg Priadel with 450mg Camcolit).

Some lithium carbonate tablets have been described as ‘slow-release’ or ‘sustained release’ but what does this mean?

When researching for our handbook for nurses, we found that blood taken from patients at hourly intervals showed a rise in blood lithium in the first few hours after taking the lithium carbonate and then the level falling again. It worked out that when lithium is taken at bedtime the maximum in the person’s blood is likely to occur early in the morning and can already be dropping at the time when a blood sample would normally be taken at the doctor’s surgery the next morning.

This means that the timing of blood tests will, to some extent, influence the result. It also means that a ‘safe’ high reading in blood taken mid-morning is no guarantee that levels were not ‘toxic’ a few hours earlier.

Carbonates tend to dissolve quicker in acid (such as stomach acid) than in water. To get an idea of how much quicker I dropped a 400mg Priadel tablet into a glass of water and a glass containing vinegar. As the photograph above shows the tablet dispersed quickly in water and even quicker in the acidic vinegar.

Are any lithium carbonate tablets really slow-release? I think not, and that I think is why no significance difference was found between Priadel ‘slow-release’ and Camcolit (that at the time of testing was not claiming to be slow-release).

Whether or not all or no lithium carbonate tablets are described as slow release, those who need or choose to continue to use lithium carbonate are likely to be fine when they need to change, from Priadel, to one of the other brands sometime before April 2021.

Here is part of a discussion of this from: The Pharmaceutical Journalthe overall outcome was that Priadel 400mg tablets were “sustained release” but had the same release as Camcolit 400mg plain tablets (the comparator in the Priadel study), Camcolit 400mg was then labelled sustained-release too. It wasn’t, but if the release was identical to the so-called ‘sustained release tablet’,Stephen Bazire22 AUG 2020 

Final photograph: After 3 hours 40 minutes, the lithium carbonate is well dispersed, although seemingly not dissolved, in the water, while fully dissolved in the acidic vinegar.

A Different Approach – ToxaPrevent

After about 11 years med-free = no prescription medications at all, I accepted a prescribed antipsychotic drug to help me sleep. I have found that I sleep a little more when I take this, yet each day I am so very tired and doing (what seems to me) to be far too little.

TOXAPREVENT ‘Tim Animation’ – “Animation about the toxins, heavy metals and histamine that affect your digestive tract and skin.”

I have met with a nutritional therapist who has suggested that my troubles may be largely due to excess toxins. If this is so, then I need a way to get these toxins out of my body (and especially out of my brain). Can this be done?

Perhaps the best hope is with a product called ToxaPrevent(R). This film explains about toxins in the body and how ToxaPrevent may do exactly what I need it to do.

The instructions I have are to take both the powder (for detoxing from upper digestive system) and the capsule(s) (for detoxing from lower digestive system) 30 minutes before each meal.

I have just taken first dose of each, so now to cook, eat and see how I feel later.

If your life were planned for you

“If your life were planned for you…” Has it ever seemed to you that everything that happens has been pre-planned? Little bits of deja vue perhaps or you’ve got a good idea about what is about to happen.

I have experienced a lot of this lately. The realisation that there is a far greater power at work than I grew up believing in has been eye-opening.

I believed I was doing good. I believed I was good father for my children, a productive helpful worker at each business I worked for or at.

Looking back now, after the various interactions I have had with friends and relatives, I now question just who I was and what I was achieving. It seems I was less than I wanted to be in both ways.

Let us see what today brings. More ups and downs. More ups than downs perhaps.

Wishing you peace and love

Roger

mood success

Good behaviours can create good moods

mood-act-as-if

sad inside – ‘putting on a face’

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